Creating a Structural View of Biology - Progress and Charts
Both traditional and high-throughput structural biology strive to explain molecular and cellular functions through the use of 3D atomic models of proteins. The following charts provide a unique way to tally and view which biological functions and annotations have some level of structural data available.
Mappings were determined at either the full sequence (ORF-level) or within a specific sequence range (residue-level) that is known to fall within the region with a determined structure, depending on the level of detail used by the corresponding biological resource. Mappings are updated weekly, and show the latest biological mappings over all protein structures found in the Protein Data Bank (PDB) as well as for the set of protein structures determined as a result of PSI:Biology initiatives (2010-present).
A study to assess the impact of protein structures determined under the auspices PSI:Biology by measuring their rates of annotations was completed in May of 2013. This study examines and compares annotations assigned to structures determined under PSI:1&2, PSI:Biology in total, PSI:Biology Partnerships, and a subset of the entire set of PDB structures determined under US authors from non structural genomics studies.
Follow the links below or in the Choose bar chart menu above to begin exploring the charts for the various data sets.